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Kyung J. Kwon-Chung, National Institute of Allergy and Infectious Diseases, National Institutes of Health
John R. Perfect, Duke University Medical Center
Arturo Casadevall, Albert Einstein College of Medicine
Since its first clinical appearance in an 1890s case report, Cryptococcus has dramatically advanced as a human fungal pathogen: it now infects approximately 1 million individuals per year, resulting in more than 600,000 annual mortalities, including one-third of all AIDS-associated deaths.
Featuring more than 100 expert authors from around the world, this book offers the full range of scientific and clinical perspectives needed to create this unique, comprehensive overview of Cryptococcus. It covers both the Cryptococcus neoformans and Cryptococcus gattii species, examining in detail the life cycle, pathophysiology, molecular biology, genetics, genomics, epidemiology, immunology, and clinical management of this encapsulated yeast. Among the 44 chapters, readers will find several in-depth discussions of the C. gattii outbreak that began on Vancouver Island in 1999 and then spread into the mainland of Canada and the United States, causing infections in both humans and animals.
This book’s detailed, thorough reviews of all the latest advances and progress in the field set a new standard for publications dedicated to a single fungal pathogen. While the book is dedicated to Cryptococcus, it does draw analogies to other pathogenic fungi and, more broadly, to other microbial pathogens. Moreover, this volume demonstrates why Cryptococcus has become a model system for the study and understanding of fungal pathogenesis. As a result, molecular biologists, microbiologists, public health officials, epidemiologists, and infectious disease clinicians will all find this clearly written, carefully referenced, and all-inclusive book to be a highly valuable resource.
· Presents a broad spectrum of perspectives, spanning molecular biology, ecology, pathogenesis, immune response, and clinical management
· Provides a thorough background analysis of the basic principles, genetics, and mechanisms of this well-studied organism
· Discusses diagnosis, treatment, prevention, and other clinical perspectives on Cryptococcus infection
· Includes extensive discussion of environmental interactions and ecology
· Reviews and contextualizes the vast amount of recent findings in Cryptococcus research in a single work