Bacteria have evolved a wealth of different ways to resist the action of antibiotics, as well as to transfer these resistance traits once acquired. An important number of these mechanisms are mediated by enzymatic processes. Beta-Lactamases aminoglycoside-modifying enzymes are thoroughly discussed in this volume, as well as other enzymatic mechanisms that result in resistance. The different ways bacteria share resistance determinants, both vertically and horizontally, are also discussed. Finally, chapters offer strategies to control the dissemination of resistance genes and to combat these highly versatile inactivating enzymes.
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Hardcover, 376 pages, 8 page four-color insert, illustrations, index.
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